| 摘要 |
PROBLEM TO BE SOLVED: To provide ophthalmic, otic or nasal pharmaceutical compositions (e.g., multi-dose aqueous ophthalmic compositions) that are formulated to include a preservative, a therapeutic agent or both and a relatively low concentration of ionic solutes.SOLUTION: The present invention provides a pharmaceutical composition that includes an antimicrobial preservative and water. The antimicrobial preservative is typically significantly affected by ionic strength and is preferably selected from sorbates, non-polymeric diquaternary ammonium compounds or a combination thereof. The composition is typically aqueous and the ionic strength of the composition is typically less than 0.20, more preferably less than 0.12 and even more preferably less than 0.08 mol*L. |
