METHOD FOR PREDICTING DRUG REACTION OF TRAMADOL USING GENOTYPE OF CYP2D6 GENE

摘要

The present invention relates to a method for predicting a drug reaction of tramadol using the genotype of CYP2D6 gene and, more specifically, to a method for predicting metabolic activity of the CYP2D6 enzyme by analyzing single nucleotide polymorphism (SNP) of CYP2D6 gene of Korean people using a primer capable of analyzing SNP and using the analyzed results. Further, the present invention relates to a method for predicting a drug reaction of tramadol by effectively measuring the blood drug concentration of tramadol according to the genotype of CYP2D6 gene. The method of the present invention is useful in selecting a safe drug treatment method and developing and evaluating the personalized drug therapy by predicting a drug reaction for a patient when tramadol is alone administered or co-administered with another drug, through determination of the type of CYP2D6 of the patient. [Reference numerals] (AA) < 1.4 times; (BB) < 2.0 times; (CC) > 2.0 times