METHOD FOR PREDICTING DEVELOPMENTAL TOXICITY POSSESSED BY CHEMICAL SUBSTANCE

摘要

PROBLEM TO BE SOLVED: To provide an easy and highly-versatile method for predicting developmental toxicity possessed by a chemical substance.SOLUTION: A method for predicting developmental toxicity possessed by a chemical substance comprises: (1) a first step of measuring an expression level of one or more genes selected from a gene group including any one of a plurality of specific base sequences or orthologue genes thereof in a specimen derived from a nonhuman mammal individual or mammalian cell having come into contact with a target chemical substance; and (2) a second step of comparing the measurement value of the expression level of the gene in the specimen obtained by the first step with the reference value of the expression level of the gene, and evaluating the level of developmental toxicity possessed by the target chemical substance in the specimen based on the compared difference. In the method for predicting the developmental toxicity possessed by the chemical substance, the gene is Reln gene and the expression level of the gene is measured by measuring an amount of transcription product or translation product.