INHIBITION OF NF-&kgr;B

摘要

PROBLEM TO BE SOLVED: To identify agents that are restorable of wild type p53 activity in tumor cells.SOLUTION: Aminoacridines are inhibitors of NF-&kgr;B. Inhibiting NF-&kgr;B leads to reactivation of p53 in cancer cells with functionally blocked p53. A method for treating a condition associated with NF-&kgr;B activity comprising the step of administering to a patient in need thereof a composition comprising an inhibitor of NF-&kgr;B, in which the NF-&kgr;B activity is constitutive or induced, and may be at a basal level.