USE OF SURFACE FREE ENERGY FOR DIFFERENTIAL EVALUATION OF CRYSTAL, CRYSTAL EVALUATED ON BASIS OF SURFACE FREE ENERGY AS INDEX, AND PHARMACEUTICAL COMPOSITION PREPARED BY CONTAINING THE CRYSTAL

摘要

PROBLEM TO BE SOLVED: To provide means for suppressing the formation of an isomer of luliconazole due to influence of humidity, light and the like, thereby improving stability.SOLUTION: Disclosed is a method for differential evaluation of a crystal of luliconazole, comprising conducting the differential evaluation of the crystal by using, as indices, surface free energy of the crystal of luliconazole and a ratio of a polar component of the surface free energy, wherein the crystal is evaluated to be more stable as the surface free energy is smaller and the ratio of the polar component is lower.