发明名称 PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION
摘要 The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.
申请公布号 US2014114081(A1) 申请公布日期 2014.04.24
申请号 US201214007814 申请日期 2012.03.27
申请人 FRIESZ ANTAL;PÁRKÁNYI ZSOLT;DOMBRÁDY ZSOLT;SANOFI 发明人 FRIESZ ANTAL;PÁRKÁNYI ZSOLT;DOMBRÁDY ZSOLT
分类号 C07D307/81 主分类号 C07D307/81
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