XANTHENE DERIVATIVE

摘要

A compound having an exceptional blood-sugar-reducing effect and represented by general formula (I), and a pharmaceutically acceptable salt thereof. In the formula, X is =C(R8)-, -CH(R8)-, =N-, or -O-; Y is =C(R9)-, -CH(R9)-, or =N-; Z is =C(R10)-, -CH(R9)-, or =N-; n and m are 0-1; R8 is H or a (carboxy-1-substituted)C1-3 alkyl; R9 is H, a (carboxy-1-substituted) C1-3 alkyl, a C1-3 alkoxycarbonyl, a carboxy, or a carboxy-substituted C2-3 alkenyl; R10 is H, a C1-3 alkoxy, a (substituted) C1-3 alkyl, a C6-10 aryl, a 3-10 membered heterocycle, a C1-3 alkoxycarbonyl, a (substituted) aminocarbonyl, a carboxy-1-substituted C2-3 alkenyl, or a carboxy); R1 is H, a (substituted) C1-3 alkyl, a (substituted) C1-3 alkoxy, a (substituted) C2-3 alkenyl, a (substituted) C3-6 cycloalkyl, a C1-3 alkoxycarbonyl, a (substituted) aminocarbonyl, a 3-10-member heterocyclic carbonyl, a carboxy, or a halogen; R2 is H, a C1-3 alkyl, a C3-6 cycloalkyl, a C1-3 alkoxy, a carboxy, or a halogen; t is 1-2; R3 is H, a (carboxy-1-substituted) C1-3 alkyl, a C3-6 cycloalkyl, a (carboxy-1-substituted) C1-3 alkoxy, or carboxy; and R4, 5 and R6, 7 are C1-3 alkyls, or bond together to form a 3-6-member saturated carbon ring.