Methods and systems for diagnosing a bone disease or other condition related to collagen in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample.
申请公布号
WO2014062930(A1)
申请公布日期
2014.04.24
申请号
WO2013US65465
申请日期
2013.10.17
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人
BANASZAK HOLL, MARK M.;FISHER, GARY J.;FANG, MING;LES, CLIFFORD M.;ORR, BRADFORD G.;GOLDSTEIN, ELIZABETH;TURNER, ANTHONY