发明名称 |
Lipid-Conjugated Rhamnose for Immune System Recruitment and Oncotherapy |
摘要 |
L-Rhamnose antigen-lipid conjugates for recruitment of the immune system to sites of tumor growth for initiating an anti-tumor antigen response. Methods for introducing L-rhamnose antigen-conjugated lipids into cell membranes such that L-rhamnose antigens are displayed on the cell surface. The cells can be tumor cells and more specifically can be melanoma cells. Cells are contacted with one or more L-rhamnose antigen-lipid conjugates such that L-rhamnose antigen-lipid conjugates are inserted into the cell membrane. The cells can be contacted for example by intratumoral injection. Pharmaceutical compositions containing the L-rhamnose antigen-lipid conjugates and therapeutic methods employing the conjugates and compositions. |
申请公布号 |
US2014112975(A1) |
申请公布日期 |
2014.04.24 |
申请号 |
US201313842800 |
申请日期 |
2013.03.15 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
KIESSLING LAURA L.;SHERIDAN RACHAEL T.C.;HUDON JONATHAN |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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