The embodiments provide prodrug compounds of Formulae I-XV. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XV that provides controlled release of an opioid. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
申请公布号
WO2012122420(A3)
申请公布日期
2014.04.24
申请号
WO2012US28365
申请日期
2012.03.08
申请人
SIGNATURE THERAPEUTICS, INC.;JENKINS, THOMAS E.;HUSFELD, CRAIG O.