THY1 (CD90) AS A NOVEL THERAPY TO CONTROL ADIPOSE TISSUE ACCUMULATION

摘要

The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thyl protein or polypeptide fragment thereof, or an agent that enhances Thyl expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thyl protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thyl expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis.