发明名称 |
ANTI-JAGGED 1/JAGGED 2 CROSS-REACTIVE ANTIBODIES, ACTIVATABLE ANTI-JAGGED ANTIBODIES AND METHODS OF USE THEREOF |
摘要 |
This invention relates generally to the generation of antibodies, e.g., monoclonal antibodies including fully human monoclonal antibodies, that recognize Jagged 1 and/or Jagged 2, to antibodies, e.g., monoclonal antibodies including fully human antibodies that recognize Jagged 1 and/or Jagged 2, and nucleic acid molecules that encode antibodies, e.g., nucleic acid molecules that encode monoclonal antibodies including fully human cross-reactive antibodies that recognize both Jagged 1 and Jagged 2, and to methods of making the anti- Jagged antibodies and methods of using the anti- Jagged antibodies as therapeutics, prophylactics, and diagnostics. The invention also relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically bind to Jagged 1 and Jagged 2, and to methods of making and using these activatable anti- Jagged antibodies in a variety of therapeutic, diagnostic and prophylactic indications. |
申请公布号 |
WO2013192550(A3) |
申请公布日期 |
2014.04.24 |
申请号 |
WO2013US47109 |
申请日期 |
2013.06.21 |
申请人 |
CYTOMX THERAPEUTICS, INC. |
发明人 |
WEST, JAMES, WILLIAM;SAGERT, JASON, GARY;BESSETTE, PAUL, H.;LOWMAN, HENRY, BERNARD;STAGLIANO, NANCY, E.;VASILJEVA, OLGA;MENENDEZ, ELIZABETH-EDNA, MARY |
分类号 |
A61K39/395;A61P35/00;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
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地址 |
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