The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.
申请公布号
AU2008299784(B2)
申请公布日期
2014.04.24
申请号
AU20080299784
申请日期
2008.08.01
申请人
GILEAD BIOLOGICS, INC.
发明人
BIERMANN, DONNA HIROKO TOKUOKA;BARRY, VIVIAN E.;OYASU, MIHO;MARSHALL, DEREK;HOLZER, ALISON KAY;SMITH, VICTORIA;GARCIA, CARLOS AURELIO;VAN VLASSELAER, PETER;MCCAULEY, SCOTT ALAN;RODRIGUEZ, HECTOR;OGG, SCOTT