发明名称 |
MAMMALIAN CELL CULTURE PROCESSES FOR PROTEIN PRODUCTION |
摘要 |
The present invention describes methods and processes for the production of proteins by animal cell or mammalian cell culture. In one aspect, the methods comprise the growth of cells in a growth factor/protein/peptide free medium. In another aspect, the methods comprise the addition of growth factors during the production phase. The methods sustain a high viability of the cultured cells, and can yield an increased end titer of protein product, and a high quality of protein product. |
申请公布号 |
WO2014062535(A1) |
申请公布日期 |
2014.04.24 |
申请号 |
WO2013US64758 |
申请日期 |
2013.10.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
TIAN, JUN;BORYS, MICHAEL;LI, ZHENGJIAN;ABUABSI, NICHOLAS;AU, ANGELA;QIAN, NAN-XIN;DAI, XIAO-PING |
分类号 |
C12N5/00;C12N15/62;C12N15/63;C12P21/02 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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