摘要 |
<p>The instant invention relates to methods for the treatment of neuroblastoma by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is CHK1-1 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a neuroblastoma patient, comprising administering a WEE1 inhibitor and a CHK1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by amplified expression levels of MYCN.</p> |
申请人 |
MERCK SHARP & DOHME CORP.;CHILDREN'S HOSPITAL OF PHILADELPHIA;COLE, KRISTINA;MARIS, JOHN;RUSSELL, MICHAEL;BENITA, YAIR;KUBICA, JAMIE;SHUMWAY, STUART DENHAM |
发明人 |
COLE, KRISTINA;MARIS, JOHN;RUSSELL, MICHAEL;BENITA, YAIR;KUBICA, JAMIE;SHUMWAY, STUART DENHAM |