发明名称 |
IMMUNOMODULATORY PROTEINS |
摘要 |
<p>A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.</p> |
申请公布号 |
CA2888519(A1) |
申请公布日期 |
2014.04.24 |
申请号 |
CA20122888519 |
申请日期 |
2012.10.17 |
申请人 |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE |
发明人 |
PLEASS, RICHARD JOHN |
分类号 |
C07K16/00;A61K39/395;A61P37/00;C07K14/735;C12N15/13 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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