| 摘要 |
PROBLEM TO BE SOLVED: To provide a method and a composition of treating or preventing of non-tauopathy neurological disorders by enhancement of the activity of protein phosphatase PP2A associated with the phosphorylation of tau protein.SOLUTION: A method of treating or preventing of non-tauopathy neurological disorders in a subject comprises the step of administering an effective amount of selenate or a pharmaceutically acceptable salt thereof, to inhibit the hyperphosphorylation of tau protein. The non-tauopathy neurological disorder is not an α-synucleopathy. The neurological disorder is selected from the group consisting of Creutzfeldt-Jakob disease, Huntington's disease, stroke, cerebral ischaemia, dementia associated with stroke or cerebral ischaemia, dementia associated with HIV, disorders associated with excitotoxicity, epilepsy, seizures, schizophrenia, multiple sclerosis, acute brain trauma (severe traumatic brain injury) and oxygen glucose deprivation. The supranutritional amount of selenium is 5 μg/kg to 0.1 g/kg per day, and the selenate is in the form of sodium selenate. |
