摘要 |
<p>Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer. Also provided are methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Cancers that are treatable by the compounds of the invention are glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non-small cell lung cancer, chondrosarcoma, and non-Hodgkin's lymphoma (NHL).</p> |
申请人 |
AGIOS PHARMACEUTICALS, INC. |
发明人 |
POPOVICI-MULLER, JANETA;SALITURO, FRANCESCO GERALD;SAUNDERS, JEFFREY OWEN;TRAVINS, JEREMY;YAN, SHUNQI |