发明名称 |
Dispiro 1,2,4-trioxolane antimalarials |
摘要 |
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer. |
申请公布号 |
AU2008318819(C1) |
申请公布日期 |
2014.04.24 |
申请号 |
AU20080318819 |
申请日期 |
2008.10.29 |
申请人 |
MMV MEDICINES FOR MALARIA VENTURE |
发明人 |
MATILE, HUGUES;VENNERSTROM, JONATHAN L.;CREEK, DARREN J.;CHOLLET, JACQUES;SRIRAGHAVAN, KAMARAJ;CHARMAN, SUSAN A.;CHARMAN, WILLIAM N.;WANG, XIAOFANG;WITTLIN, SERGIO;ZHOU, LIN;DONG, YUXIANG |
分类号 |
C07D493/10;A61K31/343;A61K31/4525;A61K31/496;A61K31/5377;A61K31/541;A61K31/553;A61P33/06 |
主分类号 |
C07D493/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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