DISUBSTITUTED MALEIC ANHYDRIDES WITH ALTERED KINETICS OF RING CLOSURE
摘要
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
申请公布号
EP2720540(A1)
申请公布日期
2014.04.23
申请号
EP20120801275
申请日期
2012.05.31
申请人
ARROWHEAD MADISON INC.
发明人
BLOKHIN, ANDREI, V.;ROZEMA, DAVID, B.;BENSON, JONATHAN, D.;CARLSON, JEFFREY, C.