发明名称 |
COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA |
摘要 |
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure. |
申请公布号 |
EP2721158(A1) |
申请公布日期 |
2014.04.23 |
申请号 |
EP20120802232 |
申请日期 |
2012.06.20 |
申请人 |
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
ROSS, TED, M.;GILES, BRENDAN, M.;CREVAR, COREY, J. |
分类号 |
C07K14/11;A61K39/145;C12N15/44 |
主分类号 |
C07K14/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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