| 摘要 |
Traditional photodynamic therapy (PDT) is a method of using a visible light with a certain wavelength to irradiate photofrin, converting O 2 into 1 O 2 by energy conversion for treatment of diseases, and many photofrin kinds of new drugs have been marketed and widely used in clinic. The present invention relates to therapeutical mechanism totally different from PDT, in which the specific affinity of photofrin to focus, such as tumors, vascular plaques and skin diseases, is utilized, and a certain means is used to activate photofrin in the focus, catalyze the decomposition reaction of H 2 O 2 to generate 1 O 2 in the focus, 1 O 2 further induces apoptosis and necrosis of cells with pathological changes, the purpose of treating tumors, vascular plaques and skin diseases is achieved, and cosmetic effects on skin are prompted. A series of new drugs obtained via the screening and studying of the present invention are used for Chemodynamic Therapy (CDT), or for Radiochemodynamic Therapy (RCDT) carried out via radioactive rays. The action mechanism of the drugs is as follows: In the formula, photofrin can be endogenous (e.g., 5-ALA synthetic endogenous porphyrin), or exogenous; H 2 O 2 can be exogenous, or can be endogenous H 2 O 2 generated by means of hydrogen peroxidase inhibitor; the activation of photofrin is carried out by specific protein binding or by electron beam, x-ray, r-ray, or other means. In comparison with traditional photodynamic therapy (PDT), CDT and RCDT have advantages in: no need for light source; no need for oxygen; able to be quantitated; no need for intervention means; good therapeutical effects; simpler operation; capable of being repeated therapy; easy for popularization and application. The present invention relates to a series of new drugs useful in CDT and RCDT. The series of new drugs refer to chemical series capable of catalyzing the decomposition of H 2 O 2 to generate singlet oxygen ( 1 O 2 ). They have no notable side effects on human body, at same time have affinity to focus of disease. Under this kind of therapeutic model, photofrin acts as a catalyst for chemical reaction, its mechanism, use and therapeutical effects are totally different from the traditional photodynamic therapy, unnecessary for oxygen and visible light, and form an independent series of new drug. The present patent is to protect the intellectual property of the series of drugs. |
