发明名称 |
ENZYME-RESPONSIVE GRAPHENE OXIDE/BIOPOLYMER-PHOTOSENSITIZER NANOCOMPLEX AND COMPOSITION FOR FLUORESCENCE IMAGE AND PHOTODYNAMIC/PHOTOTHERMAL TREATMENT COMPRISING THEREOF |
摘要 |
The present invention relates to a nanocomplex in which the fluorescence and reactive oxygen generation are activated by the action of a specific enzyme overexpressed in cancer cells, and more specifically, to a graphene oxide/biopolymer-photosensitizer nanocomplex for a cancer cell selective fluorescence image or photothermal treatment which is obtained by combining graphene oxide to a responsive binder. The graphene oxide/biopolymer-photosensitizer anocomplex according to the present invention selectively reacts to an enzyme expressed in the cancer cells and generates a strong fluorescence signal, and generates reactive oxygen species and heat. Therefore, the graphene oxide/biopolymer-photosensitizer anocomplex according to the present invention can be applied to not only the fluorescence image diagnosis but also the photodynamic/photothermal treatment of cancer. [Reference numerals] (AA,BB) Light; (CC) Biopolymer-photosensitizer binder; (DD) Graphene oxide |
申请公布号 |
KR20140048008(A) |
申请公布日期 |
2014.04.23 |
申请号 |
KR20120114467 |
申请日期 |
2012.10.15 |
申请人 |
NATIONAL CANCER CENTER |
发明人 |
CHOI, YONG DOO;CHO, YOUNG NAM;KIM, IN HOO |
分类号 |
A61K47/48;A61K47/30;A61K49/12;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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