发明名称 |
ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME |
摘要 |
<p>Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents any one selected from 11CH3, CH2 18F and CF2 18F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.</p> |
申请公布号 |
EP2463263(B1) |
申请公布日期 |
2014.04.23 |
申请号 |
EP20100806375 |
申请日期 |
2010.07.29 |
申请人 |
RIKEN |
发明人 |
TAKASHIMA, MISATO;SHUKURI, MIHO;GOTO, MIKI;DOI, HISASHI;ONOE, HIROTAKA;SUZUKI, MASAAKI;WATANABE, YASUYOSHI |
分类号 |
C07C57/30;A61K51/00;C07C51/353;C07C57/58;C07C59/64;C07C59/68;C07C59/84;C07C59/86;C07C67/333;C07C69/612;C07C69/65;C07C69/734;C07C69/736;C07C69/738;G01T1/161 |
主分类号 |
C07C57/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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