发明名称 |
CILIARY NEUROTROPHIC FACTOR VARIANTS |
摘要 |
Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue. |
申请公布号 |
EP2720709(A1) |
申请公布日期 |
2014.04.23 |
申请号 |
EP20120727648 |
申请日期 |
2012.06.13 |
申请人 |
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL |
发明人 |
GROETZINGER, JOACHIM;ROSE-JOHN, STEFAN;SCHELLER, JUERGEN;AURICH, MATTHIAS |
分类号 |
A61K38/00;C07K14/475;C07K14/48 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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