发明名称 |
Method for obtaining biologically active recombinant human G-CSF |
摘要 |
Provided is a method of obtaining biologically active recombinant human G-CSF from inclusion bodies, wherein the solubilization and refolding process can be performed at ambient temperature and the purification step comprises reversed phase chromatography (RP), in particular RP-HPLC. The G-CSF preparation so obtained is characterized by high purity and homogeneity. |
申请公布号 |
US8703123(B2) |
申请公布日期 |
2014.04.22 |
申请号 |
US201113634801 |
申请日期 |
2011.03.17 |
申请人 |
HINDERER WALTER;SCHECKERMANN CHRISTIAN;BIOGENERIX GMBH |
发明人 |
HINDERER WALTER;SCHECKERMANN CHRISTIAN |
分类号 |
A61K35/00;C07K1/16;C07K1/18;C07K1/20 |
主分类号 |
A61K35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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