发明名称 |
Salmonella vectored vaccines against Chlamydia and methods of use |
摘要 |
The invention provides an attenuated Salmonella vaccine vector comprising one or more heterologous polynucleotides that encode immunogenic Chlamydial peptides. In one embodiment, the attenuated Salmonella vaccine vector comprises aroC and ssaV attenuating mutations. The heterologous polynucleotides encoding the immunogenic Chlamydial peptides can be under the control of an inducible promoter such as a Salmonella ssaG promoter. In one embodiment of the invention, the immunogenic Chlamydial peptide is a PmpG peptide, for instance, a CT110, CT84 or CT40 peptide. |
申请公布号 |
US8703153(B2) |
申请公布日期 |
2014.04.22 |
申请号 |
US20090999246 |
申请日期 |
2009.06.16 |
申请人 |
TELFER JONATHAN LEWIS;REDFERN MARK RICHARD;LACY MICHAEL JOSEPH;PROKARIUM LTD. |
发明人 |
TELFER JONATHAN LEWIS;REDFERN MARK RICHARD;LACY MICHAEL JOSEPH |
分类号 |
A61K39/112;A61K48/00;A61K49/00 |
主分类号 |
A61K39/112 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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