发明名称 |
Low ABUK oxycodone, its salts and methods of making same |
摘要 |
A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone. |
申请公布号 |
US8703950(B2) |
申请公布日期 |
2014.04.22 |
申请号 |
US201113175537 |
申请日期 |
2011.07.01 |
申请人 |
KESKENY ERNO M.;MENCEL JAMES J.;DUNG JEN-SEN;JOHNSON MATTHEY PUBLIC LIMITED CO. |
发明人 |
KESKENY ERNO M.;MENCEL JAMES J.;DUNG JEN-SEN |
分类号 |
C07D489/02;C07D489/04;C07D489/08 |
主分类号 |
C07D489/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|