| 摘要 |
PROBLEM TO BE SOLVED: To provide type-I interferon (IFN) and IFNα-induced pharmacodynamic marker (PD marker) expression profiles, kits, and methods for identifying such IFNα-induced PD marker expression profiles.SOLUTION: Provided is a method of identifying a systemic lupus erythematosus patient as a candidate for an antibody that binds to IFNα and modulates its activity comprising: detecting presence or absence of an IFNα-inducible PD marker expression profile in a sample from the patient, wherein detecting presence of the PD marker expression profile identifies the patient as a candidate for the antibody that binds to IFNα and modulates its activity, and wherein the PD marker expression profile comprises up-regulated expression or activity of specific genes. |
