发明名称 |
CAPSID-FREE AAV VECTORS, COMPOSITIONS, AND METHODS FOR VECTOR PRODUCTION AND GENE DELIVERY |
摘要 |
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided. |
申请公布号 |
US2014107186(A1) |
申请公布日期 |
2014.04.17 |
申请号 |
US201214004379 |
申请日期 |
2012.03.12 |
申请人 |
GARCIA LUIS;BELEY CYRIAQUE;VOIT THOMAS;KOTIN ROBERT MICHAEL;ASSOCIATION INSTITUT DE MYOLOGIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) |
发明人 |
GARCIA LUIS;BELEY CYRIAQUE;VOIT THOMAS;KOTIN ROBERT MICHAEL |
分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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