| 发明名称 |
DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS |
| 摘要 |
The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. |
| 申请公布号 |
US2014107120(A1) |
申请公布日期 |
2014.04.17 |
| 申请号 |
US201314132391 |
申请日期 |
2013.12.18 |
| 申请人 |
ALLEGRETTI PAUL;CHOI SEOK-KI;FATHEREE PAUL R.;GENDRON ROLAND;HUDSON RYAN;JENDZA KEITH;MCKINNELL ROBERT MURRAY;MCMURTRIE DARREN;OLSON BROOKE;THERAVANCE, INC. |
发明人 |
ALLEGRETTI PAUL;CHOI SEOK-KI;FATHEREE PAUL R.;GENDRON ROLAND;HUDSON RYAN;JENDZA KEITH;MCKINNELL ROBERT MURRAY;MCMURTRIE DARREN;OLSON BROOKE |
| 分类号 |
A61K31/4184;A61K31/4439;A61K31/5377;A61K45/06;C07D235/08;C07D401/12;C07D403/10;C07D405/10 |
主分类号 |
A61K31/4184 |
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