发明名称 |
METHODS FOR IDENTIFYING INHIBITORS OF ABETA42 OLIGOMERS |
摘要 |
The invention herein is directed to immunoassays for the detection of Aβ42 oligomers. The inventive assays are based on the observations herein that the presence of Aβ42 oligomers in a preparation is directly related to a decrease in a C-terminal (CT) immunosignal and a correlated increase in an N-terminal (NT) immunosignal, relative to the immunosignal generated in the absence of Aβ42 oligomers, in an Aβ42 CT and NT ELISA assay and an Aβ42 CT AlphaLISA assay. The invention herein involves the use of these assays alone or in combination to screen for inhibitors of Aβ42 oligomerization. |
申请公布号 |
US2014106380(A1) |
申请公布日期 |
2014.04.17 |
申请号 |
US201314106468 |
申请日期 |
2013.12.13 |
申请人 |
MERCK SHARP & DOHME CROP. |
发明人 |
MCCAMPBELL ALEXANDER;RAY WILLIAM J.;TOOLAN DAWN M.;ZHAO WEI-QIN |
分类号 |
G01N33/566 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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地址 |
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