Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Ra locus of mouse ectodomain- encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
申请公布号
WO2013063556(A8)
申请公布日期
2014.04.17
申请号
WO2012US62379
申请日期
2012.10.29
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
WANG, LI-HSIEN;DORE, JR., ANTHONY, T.;STEVENS, SEAN;MURPHY, ANDREW, J.