| 摘要 |
The proposed compositions and methods for preparation thereof relate to pharmacology, medicine, veterinary science and pharmaceutical industry. The compositions can be used for preparing infusion solutions of antimicrobial (antibacterial and antifungal) preparations increasing therapeutic efficiency thereof. The compositions include nanostructured colloidal silica and are efficient when treating overwhelming sepsis of tested animals, provoked by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The pharmaceutical compositions have a proven and significant clinically important potentiating impact on therapeutic efficiency of the infusion solutions, when treating inflammatory diseases, in comparison with traditional solvents. The methods include—obtaining a mixture of colloidal silica with sodium chloride or with dextrose in a certain weight ratio, which mixture includes a mass fraction of fine-dispersed particles of colloidal silica, having dimensions not exceeding 5 micrometers, and—subjecting the mixture to impacting-abrasive actions, until the mass fraction is increased at least twice. |
