| 摘要 |
The present disclosure relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus. The gougerotin gene cluster further comprises another 11 ORFs, which are also disclosed. Gougerotin analogs and methods for producing them by manipulation of the gougerotin gene cluster and the genes therein are also disclosed. |
