| 发明名称 |
BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY |
| 摘要 |
<p>A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition.</p> |
| 申请公布号 |
WO2014059446(A1) |
申请公布日期 |
2014.04.17 |
| 申请号 |
WO2013US65145 |
申请日期 |
2013.10.15 |
| 申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
ALSBERG, EBEN;NGUYEN, MINH, KHANH;HUYNH, CONG;GILEWSKI, ALEX;LEVY, MATT;ROTELLO, VINCENT;YESILBAG, GULEN;JEON, OJU |
| 分类号 |
C08L5/00;C08L23/04;C08L29/04;C08L29/10;C08L33/00;C08L75/00;C08L99/00 |
主分类号 |
C08L5/00 |
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