| 摘要 |
A cyclotide sequence defined as anon-naturally occurring linear or cyclic peptide having a cysteine knot backbone moiety and a defined blood-brain barrier translocation moiety, said peptide molecule comprising: i) a peptide having said blood-brain barrier translocation activity, wherein said peptide has an amino acid sequence comprising a plurality of contiguous amino acids, wherein said peptide is about 6to 50 amino acid residues; and ii) a cysteine knot backbone grafted to said peptide of step i). |
