发明名称 ANTIBODY-DRUG CONJUGATE
摘要 Provided is an antibody-drug conjugate which can be used as an anti-tumor agent that has an excellent anti-tumor effect and is highly safe, said conjugate being characterized by being produced by binding an anti-tumor compound represented by formula (1) to an antibody through a linker having a structure represented by the formula: -L1-L2-LP-NH-(CH2)n1-La-Lb-Lc- (wherein the antibody is bound at the terminal of L1, and the anti-tumor compound is bound at the terminal of Lc in which the binding site of the anti-tumor compound is a nitrogen atom in an amino group located at position-1).
申请公布号 CA2885800(A1) 申请公布日期 2014.04.17
申请号 CA20132885800 申请日期 2013.10.10
申请人 DAIICHI SANKYO COMPANY, LIMITED 发明人 MASUDA, TAKESHI;NAITO, HIROYUKI;NAKADA, TAKASHI;YOSHIDA, MASAO;ASHIDA, SHINJI;MIYAZAKI, HIDEKI;KASUYA, YUJI;MORITA, KOJI;ABE, YUKI;OGITANI, YUSUKE
分类号 C07K5/103;A61K47/48;A61P35/00;C07D207/404;C07D491/22;C07K5/00;C07K7/06;C07K16/30 主分类号 C07K5/103
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