发明名称 |
ANTI-CANCER LEAD MOLECULE |
摘要 |
Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative‘A’(Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer and has shown low hepatotoxicity as well as overall lower toxicity in nude mice model. The toxicity of derivative‘A’was determined to be even lower than vehicle control (ALT and AST markers). The possible mechanism of action identified based on the microarray experiments and pathway mapping shows that derivative‘A’could be acting by altering the cholesterol-related mechanisms. The low toxicity profile of derivative‘A’highlights its possible role'as future anti-cancer drug and/or as an adjuvant drug to reduce the toxicity of highly toxic chemotherapeutic'drugs. |
申请公布号 |
US2014107196(A1) |
申请公布日期 |
2014.04.17 |
申请号 |
US201313802430 |
申请日期 |
2013.03.13 |
申请人 |
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY;KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY |
发明人 |
SAGAR SUNIL;KAUR MANDEEP;ESAU LUKE E. |
分类号 |
A61K31/235;A61K45/06;C07C69/157 |
主分类号 |
A61K31/235 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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