(2R)-2-DEOXY-2,2-DISUBSTITUTE-1,4-RIBOSE LACTONE AND PREPARATION METHOD AND USE THEREOF

摘要

Disclosed in the invention is a single configuration(2R)-2-deoxy-2,2-disubstitute-1,4-ribose lactone and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstitute-1,4-ribose lactone of the following general formula V provided in the invention or pharmaceutically acceptable salts, esters, prodrugs or solvates thereof are important intermediates of a variety of anti-virus and anti-tumour active ingredients. The compound of general formula (VI) obtained by the acylation reaction of the compound of general formula (V) can be directly used for preparing various anti-virus and anti-tumour drugs. The chiral synthesis method and the crystallization resolution method of the compound of general formula (V) provided in the invention have the following advantages: the routes are short, the methods are simple, yields are high, and the cost is low, and they are suitable for industrial production.