| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions and methods of synthesis and use of F-19 labeled molecules of use, labeling a target site rapidly and simply using Positron Emission Tomography (PET) imaging techniques.SOLUTION: The labeled molecules may be peptides, or proteins, aptamers etc., and other types of molecules may be used. The F-19 label may be conjugated to a targeting molecule by formation of a metal complex and binding of the metal complex to a chelating moiety, such as DOTA. The metal may first be conjugated to the chelating group and subsequently the F-19 bound to the metal. The F-19 labeled moiety may comprise a targetable conjugate that may be used in combination with a bispecific or multispecific antibody to target the F-19 to an antigen expressed on a cell or tissue associated with a disease, medical condition, or pathogen. F-19 labeled targetable conjugate peptides are stable in human serum at 37°C for several hours. |
