摘要 |
The invention relates to hypophosphorous acid derivatives of formula (I) wherein—X is H or OH,—R represents one or several radicals R1-R5, identical or different, two of R1-R5 optionally occupying the same position on the phenyl group, one to four of R1-R5 being H and the others being selected in the group comprising -0-(CH2)n—COOH;—S—(CH2)n—COOH;—NH—(CH2)n—COOH; -0-(CH,R′)—COOH;—O—(CH2)n—OH; OR′,—R′being a C1-C3 alkyl radical;—OH;—COOH; halogen, particularly—F,—CI,—Br,—I,—CF3;—OCF3;—N02;—CH═CH—COOH;—(CH2)n—COOH; O—(CH2)n—P03H2; O—(CF2)n—P03H2; O—(CH2)n—S03H; O—(CH2)n—CONHOH; O—(CH2)n-tetrazol; O—(CH2)n-hydroxyisoxazol—n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers. |