发明名称 STRUCTURAL MODIFICATION OF 19-NORPROGESTERONE I: 17-ALPHA-SUBSTITUTED-11-BETA-SUBSTITUTED-4-ARYL AND 21-SUBSTITUTED 19-NORPREGNADIENEDIONE AS NEW ANTIPROGESTATIONAL AGENTS
摘要 Disclosed are compounds having the general formula: wherein R1-R4 and X are as defined herein, pharmaceutical compositions including such compounds, and a method of treating a patient involving antagonizing the endogenous progesterone, such as in inducing menses and treating endometriosis, dysmenorrhea, endocrine hormone-dependent tumors, meningiomas, uterine leiomyomas, or uterine fibroids, inhibiting uterine endometrial proliferation, inducing cervical ripening, inducing labor, and in contraception.
申请公布号 US2014107089(A1) 申请公布日期 2014.04.17
申请号 US201314023131 申请日期 2013.09.10
申请人 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV 发明人 KIM HYUN K.;BLYE RICHARD P.;RAO PEMMARAJU N.;CESSAC JAMES W.;ACOSTA CARMIE K.;SIMMONS ANNE MARIE
分类号 C07J41/00;C07J5/00;C07J7/00;C07J9/00;C07J21/00;C07J31/00;C07J43/00;C07J51/00;C07J71/00 主分类号 C07J41/00
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