METHOD OF DETERMINATION OF NEUTRAL DNA SEQUENCES IN THE GENOME, SYSTEM FOR TARGETING SEQUENCES OBTAINED THEREBY AND METHODS FOR USE THEREOF

摘要

The present invention relates to the method for identification of neutral DNA sequences suitable for integration of DNA of interest in any partially or completely annotated sequence or genome. The invention further relates to the identified neutral sequences which are suitable for integration of DNA of interest, the method for inserting a DNA of interest into the genome of interest. Furthermore, the invention relates to the cell and/or organ ism which have integrated DNA of interest in the neutral sequence and their use in the production of cell lines, transgenic plants and animals and for gene therapy.