| 摘要 |
<p>Process methods for making the dual m TOR/PI3K inhibitor GDC-0980, named as (S)-1- (4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6- yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.</p> |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;GENENTECH, INC. |
发明人 |
BABU, SRINIVASAN;CHENG, ZHIGANG;GOSSELIN, FRANCIS;HIDBER, PIRMIN;HOFFMANN, URSULA;HUMPHRIES, THERESA;REENTS, REINHARD;TIAN, QINGPING;YAJIMA, HERBERT |
