SUSTAINED RELEASE FORMULATIONS FOR DELIVERY OF PROTEINS TO THE EYE AND METHODS OF PREPARING SAME

摘要

The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5μL to 100μL of the formulation provides for sustained release of the agent for at least 14 days.