| 摘要 |
<p>The present invention relates to a process for producing (1S,6S)- or (1R,6R)-cis-2,8-diazabicyclo[4.3,0]nonane with high optical purity by forming a salt from a (1S,6R)- or (1R,6S)-cis-7,9-dioxo-8-substituted-2,8-diazabicyclo[4.3.0]nonane derivative and an acid, precipitating the salt with high excess diastereomer ratio as a solid, reducing the solid, and removing the substituent on the nitrogen atom at 8-position. According to the present invention, it is possible to easily and effectively produce (lS,6S)- or (1R,6R)-cis-2,8-diazabicyclo[4.3.0]nonane or the salt thereof with high optical purity without troublesome procedure from inexpensive and versatile starting material. The target compound is important as a raw material for a medicine.</p> |
