发明名称 |
SUBMICRO EMULSION OF PACLITAXEL USING STEROID COMPLEX AS INTERMEDIATE CARRIER |
摘要 |
<p>A submicron emulsion of paclitaxel, the preparation method and the use thereof are disclosed. Said paclitaxel submicron emulsion comprises paclitarxel/steroid complex, oil for injection, water for injection, emulsifier, assistant emulsifier and isotonic agent, wherein the mole ratio of paclitaxel to steroid in the complex is 1:0.2ˆ¼4; preferably 1:0.25-2. Said submicron emulsion is useful for the treatment for malignant tumor. The average particle diameter of the submicron emulsion is less than 400 nm and the pH Value is 3.5-6.</p> |
申请公布号 |
EP2494957(A4) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20100826102 |
申请日期 |
2010.10.28 |
申请人 |
INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES |
发明人 |
LIU, YULING;XIA, XUEJUN;GUO, RUIFANG;ZHANG, PENGXIAO;HAN, RUI;FU, ZHAODI;ZHOU, CUIPING;WANG, RENYUN;JIN, DUJIA |
分类号 |
A61K9/107;A61K31/337;A61K47/28;A61K47/44;A61P35/00 |
主分类号 |
A61K9/107 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|