SYSTEMS AND METHODS FOR QUANTIFYING THE IMPACT OF BIOLOGICAL PERTURBATIONS

摘要

Systems and methods are provided for generating a biological impact factor that quantifies the perturbation of a biological system using response data and computational network models of the underlying biological mechanisms. The biological impact factor represents the long-term effect of the perturbation on an outcome. As an example, the systems and methods may generate a biological impact factor representing the progression of lung cancer based on an exposure to cigarette smoke.