发明名称 |
N-HYDROXYFORMAMIDE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME |
摘要 |
A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof:
wherein X represents a phenylene group; Y represents a hydrogen atom, -(CH 2 ) m R 1 or the like; R 1 represents -NR 5 COR 2 , -NR 5 SO 2 R 2 or -NR 3 R 4 ; R 2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group; R 3 and R 4 represent a C1-C6 alkyl group and the like; R 5 represents a hydrogen atom or a C1-C6 alkyl group or the like; m indicates an integer of from 0 to 4; and Z represents a hydrogen atom or a C1-C6 alkyl group. |
申请公布号 |
EP2597084(A4) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20110803563 |
申请日期 |
2011.07.05 |
申请人 |
KAKEN PHARMACEUTICAL CO., LTD. |
发明人 |
KAWAI KENTARO;MIYAMOTO SHIGERU;SHIMANO MASANAO;HAINO MAKOTO |
分类号 |
C07C317/40;A61K31/16;A61K31/5375;A61P1/02;A61P1/04;A61P11/06;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P25/00;A61P31/00;A61P31/04;A61P35/00;A61P37/00;A61P43/00;C07D295/12 |
主分类号 |
C07C317/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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